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Clinical outcomes of rare hepatocellular carcinoma variants compared to pure hepatocellular carcinoma
- Source :
- Journal of Hepatocellular Carcinoma. 6:119-129
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- Background HCC variants are rare primary hepatic tumors. The aim of this study is to compare clinical characteristics and outcomes of HCC variants with pure HCC. Methods Patients diagnosed between 2004 and 2013 with ICD-O-3 8180/3 and 8170/3-8175/3 were identified from the National Cancer Database. Univariate and multivariate survival analyses were conducted to analyze the association between histology and overall survival (OS). Results 80,280 patients were identified; pure HCC 78,461 (97.7%), fibrolamellar (FLHCC) 310 (0.4%), scirrhous 161 (0.2%), spindle cell 72 (0.1%), clear cell 487 (0.6%), pleomorphic 23 (0.0%), and combined HCC and cholangiocarcinoma (mixed HCC) 766 (1.0%). 76.7% were male and 72% Caucasian. Liver transplant was performed in 10.1% of pure HCC, 14.5% of mixed HCC, 16.2% of scirrhous, 6.9% of spindle cell, 8.8% of clear cell, 8.7% of pleomorphic, and 3.2% of FLHCC (p
- Subjects :
- Surgical resection
medicine.medical_specialty
Chemotherapy
business.industry
medicine.medical_treatment
Cancer
Histology
medicine.disease
Multivariate survival
Gastroenterology
digestive system diseases
03 medical and health sciences
0302 clinical medicine
030220 oncology & carcinogenesis
Internal medicine
Hepatocellular carcinoma
medicine
Overall survival
030211 gastroenterology & hepatology
business
neoplasms
Clear cell
Subjects
Details
- ISSN :
- 22535969
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of Hepatocellular Carcinoma
- Accession number :
- edsair.doi...........584071ed0c61e74d255a7e63c5ad6b46