ChemInform Abstract: Synthesis of Pentasubstituted Pyrroles via Catalyst-Free Multicomponent Reactions

A facile and versatile catalyst-free method for the preparation of a wide range of pentasubstituted pyrroles has been reported using four-component reactions of arylglyoxal monohydrate, β-keto esters, amines, and various cyclic 1,3-dicarbonyls under mild reaction conditions. Employing this methodology, pseudo seven-component reactions have also been achieved in the case of p-phenylenediamine to provide conjugated bispyrroles with arene spacers.