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Comparison of QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST) for diagnosis of latent tuberculosis in haemodialysis (HD) patients: a meta-analysis ofκestimates

Authors :
Mohadeseh Sani
Salman Khazaei
Kamyar Mansori
Amin Doosti-Irani
A Sanjari Moghaddam
Erfan Ayubi
Saeid Safiri
Ehsan Mostafavi
Source :
Epidemiology and Infection. 145:1824-1833
Publication Year :
2017
Publisher :
Cambridge University Press (CUP), 2017.

Abstract

SUMMARYDiagnosis of latent tuberculosis infection (LTBI) is a concern in haemodialysis (HD) patients. Many studies have compared QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST) for detecting LTBI and reported theκstatistic of agreement between QFT-GIT and TST in HD patients. The present study aimed to systematically review this literature and conduct meta-analysis of individual studies that estimated theκbetween QFT-GIT with TST among HD patients. All relevant published studies that were available as full-text were obtained by searching Medline (1950), Web of Sciences (1945), Scopus (1973) through May 2016. Theκwas re-estimated from the individual studies and pooled using random effect meta-analysis. Subgroup analysis and meta-regression were applied to evaluate the effect of Bacillus Calmette–Guérin (BCG) vaccination, TST cut-off points, quality of studies, sample size and age on variation ofκestimate. Eight studies involving 901 HD patients were included in meta-analysis. The pooledκestimate was 0·28 (I2= 18·4%,P= 0·239, 95% confidence intervals 0·22–0·34). The discordance of TST−/QFT-GIT+ was more than TST+/QFT-GIT−. History of BCG vaccination, TST cut-off points and age are related to variation ofκestimates. TST and QFT-GIT are not comparable in detecting LTBI in HD patients. The higher TST−/QFT-GIT+ ratio compared with TST+/QFT-GIT− ratio, may indicate the superiority of QFT-GIT over TST for detection LTBI in HD patients.

Details

ISSN :
14694409 and 09502688
Volume :
145
Database :
OpenAIRE
Journal :
Epidemiology and Infection
Accession number :
edsair.doi...........581cfc7ddc503163c631d67d4b8d7ff6
Full Text :
https://doi.org/10.1017/s0950268817000334