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Naturally occurring anti‐Kp a in an infant with recurrent bacterial infection: A case report and review of the literature
- Source :
- Vox Sanguinis. 117:133-135
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Naturally occurring anti-Kpa antibody is extremely rare and was first reported in 1957, named after the first producer 'Penney'. However, the subsequent anti-Kpa reports presented were all anti-Kpa due to isoimmunization. Individuals with severe bacterial infections particularly Gram-negative bacteria are known to be capable of producing cross-reactive antibodies against Kell blood group system. However, such uncommon antibodies like anti-Kpa can be easily missed in routine pre-transfusion testing unless the panel cells containing low incidence antigen are used for antibody screening. Here, we report a case of naturally occurring anti-Kpa antibody, identified incidentally during pre-transfusion testing of a 12-month-old female infant with the diagnosis of Niemann-Pick disease and recurrent bacterial (Escherichia coli) infection.
- Subjects :
- Cross reactive antibodies
Low incidence antigen
biology
business.industry
Hematology
General Medicine
Disease
030204 cardiovascular system & hematology
Kell antigen system
biology.organism_classification
medicine.disease_cause
Microbiology
03 medical and health sciences
0302 clinical medicine
biology.protein
Medicine
Antibody
business
Antibody screening
Escherichia coli
Bacteria
030215 immunology
Subjects
Details
- ISSN :
- 14230410 and 00429007
- Volume :
- 117
- Database :
- OpenAIRE
- Journal :
- Vox Sanguinis
- Accession number :
- edsair.doi...........5801ae04a688f5eb34872b4a6b3cd75e