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Understanding crossmatch testing in organ transplantation: A case-based guide for the general nephrologist

Authors :
William R. Mulley
John Kanellis
Source :
Nephrology. 16:125-133
Publication Year :
2011
Publisher :
Wiley, 2011.

Abstract

Crossmatching of potential renal donors against potential renal transplant recipients has been performed for over 40 years and is a mandatory component of the transplant work-up process. However, gone are the days when all that was available was the T-cell complement-dependent cytotoxicity crossmatch. There are now many more options available for determining the likelihood of donor-specific antibody-mediated responses including flow crossmatching and the 'virtual' crossmatch. In addition, assays to determine the extent of sensitization of cell-mediated responses are being examined. This article builds an understanding of modern day crossmatch interpretation using a case-based approach in order to provide a framework for the general nephrologist to determine the likely immune consequences of a particular donor-recipient pairing.

Details

ISSN :
13205358
Volume :
16
Database :
OpenAIRE
Journal :
Nephrology
Accession number :
edsair.doi...........57d36fd5acd2686df1164b23c158e876
Full Text :
https://doi.org/10.1111/j.1440-1797.2010.01414.x