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Understanding crossmatch testing in organ transplantation: A case-based guide for the general nephrologist
- Source :
- Nephrology. 16:125-133
- Publication Year :
- 2011
- Publisher :
- Wiley, 2011.
-
Abstract
- Crossmatching of potential renal donors against potential renal transplant recipients has been performed for over 40 years and is a mandatory component of the transplant work-up process. However, gone are the days when all that was available was the T-cell complement-dependent cytotoxicity crossmatch. There are now many more options available for determining the likelihood of donor-specific antibody-mediated responses including flow crossmatching and the 'virtual' crossmatch. In addition, assays to determine the extent of sensitization of cell-mediated responses are being examined. This article builds an understanding of modern day crossmatch interpretation using a case-based approach in order to provide a framework for the general nephrologist to determine the likely immune consequences of a particular donor-recipient pairing.
Details
- ISSN :
- 13205358
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Nephrology
- Accession number :
- edsair.doi...........57d36fd5acd2686df1164b23c158e876
- Full Text :
- https://doi.org/10.1111/j.1440-1797.2010.01414.x