Historical Eye on IPF: A Cohort Study Redefining the Mortality Scenario

Background: Therapies that slow IPF progression are now available and recent studies suggest that the use of anti-fibrotic therapy may reduce IPF mortality. Our aim was to evaluate whether, to what extent and for which factors the survival of IPF in a real life setting has changed in the last 15 years. Methods: Historical eye is an observational study of a large cohort of consecutive IPF patients diagnosed and treated in a referral centre for ILDs with prospective intention. Findings: The study comprised 634 patients. The year 2012 identifies the time point of mortality shift ( HR 0.58, CI 0.46-0.63, p