Back to Search
Start Over
Phenotypes of CCAAT/enhancer-binding protein beta deficiency: hyperdontia and elongated coronoid process
- Source :
- Oral Diseases. 19:144-150
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- Objectives: This investigation aimed to conduct a case-control study of mandibular morphology and dental anomalies to propose a relationship between mandibular/dental phenotypes and deficiency of CCAAT/enhancer-binding protein beta (CEBPB). Materials and methods: Skulls of CEBPB(-/-) , CEBPB(+/-) and CEBPB(+/+) mice were inspected with micro-computed tomography. Mandibular morphology was assessed with a method of Euclidean distance matrix analysis. Results: Elongation of the coronoid process was identified in CEBPB(+/-) (P ≤ 0.046) and CEBPB(-/-) 12-month-olds (P ≤ 0.028) but not in 14-day-olds (P ≥ 0.217) and 0-day-olds (P ≥ 0.189) of either genotype. Formation of supernumerary teeth in CEBPB(-/-) adult mice was demonstrated (χ(2 ) =( ) 6.00, df = 1, P = 0.014). Conclusions: CEBPB deficiency was related to elongation of the coronoid process and formation of supernumerary teeth. The mandibular and dental phenotypes of CEBPB deficiency were unseen by the 14th day after birth. Future investigations into the influence of CEBPB on mandibular and dental development are needed.
- Subjects :
- Dental anomalies
medicine.medical_specialty
Mandibular morphology
Hyperdontia
Anatomy
Biology
medicine.disease
CCAAT-Enhancer-Binding Protein-beta
Phenotype
stomatognathic diseases
Coronoid process
Endocrinology
stomatognathic system
Otorhinolaryngology
Internal medicine
medicine
CEBPB
Supernumerary
General Dentistry
Subjects
Details
- ISSN :
- 1354523X
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Oral Diseases
- Accession number :
- edsair.doi...........56fe8a174e99762e249bd545cff26829
- Full Text :
- https://doi.org/10.1111/j.1601-0825.2012.01963.x