ChemInform Abstract: Modification of Biologically Active Amides and Amines with Fluoro-Containing Heterocycles. Part 5. Fluoro-Containing Heterocyclic Derivatives of 2-Amino-1,3,4-thiadiazoles

Imines, generated in situ from aminothiadiazoles (I) and methyl trifluoropyruvate (II) in the presence of the dehydrating system pyridine/thionyl chloride, undergo cyclocondensation with 1,3-C,N- and 1,3-N,N-binucleophiles such as N-substituted ureas (III), aminocrotononitrile (V), N-substituted aminouracil (VIIa) and aminothiouracil (VIId), N-substituted aminocyclohexenones (IX), and benzylbenzamidine (XI).