Fast and Selective Dehydrogenative C–H/C–H Arylation Using Mechanochemistry

A fast and site-selective biaryl synthesis via dehydrogenative C–H/C–H arylation in a ball mill was developed. In this paper, both electron-deficient oximes and electron-rich anilides quickly and under mild conditions provided arylation with various arenes to give the biaryl products in high-level selectivity. Given the solventless mechanochemical conditions, the transformation obviated the use of large amounts of arene coupling partners as solvents and allowed utilization of more-complicated and more-expensive arenes as coupling partners, which may dramatically enhance the application prospect of the C–H/C–H arylation strategy.