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Stimuli-Responsive Spherical Brushes Based on <scp>D</scp> -Galactopyranose and 2-(Dimethylamino)ethyl Methacrylate
- Source :
- Macromolecular Bioscience. 14:81-91
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- Stimuli-responsive spherical brushes composed of 6-O-methacryloyl-1,2:3,4-di-O-isopropylidene-D-galactopyranose (MAIGal) and 2-(dimethylamino)ethyl methacrylate (DMAEMA) are prepared via atom transfer radical polymerization (ATRP) using cross-linked polystyrene nanoparticles covered with a thin layer of 2-(2-bromoisobutyryloxy)ethyl methacrylate (BIEM) as ATRP initiator by the "grafting from" approach. The stimuli-responsive behavior of the deprotected spherical PMAGal-b-PDMAEMA block copolymer brushes is investigated by dynamic light scattering and cryogenic transmission electron microscopy. A brush with arms containing 160 MAGal and 170 DMAEMA monomer units shows a significant contraction of the hydrodynamic radius from 20 to 70 °C at pH = 8 with a cloud point at ≈40 °C, whereas no LCST is detected at pH = 6 and 7 due to the protonation of the DMAEMA units. Aggregates occur at low temperatures and pH 8 due to intermolecular interactions between the chains of different brushes, which disappear above LCST, when the PDMAEMA chains fold back to the core of the brushes, exposing the glycopolymer chains to the outside.
- Subjects :
- Hydrodynamic radius
Materials science
Polymers and Plastics
Atom-transfer radical-polymerization
Glycopolymer
Bioengineering
Methacrylate
Lower critical solution temperature
Biomaterials
chemistry.chemical_compound
Monomer
chemistry
Dynamic light scattering
Polymer chemistry
Materials Chemistry
Copolymer
Biotechnology
Subjects
Details
- ISSN :
- 16165187
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Macromolecular Bioscience
- Accession number :
- edsair.doi...........566dbb043e3737021bb1b38577dc84ea