The Role of Haplo-Identical Bone Marrow Transfusion in ALG Treated Patients with Severe Aplastic Anemia (SAA)

Immunosuppression with ALG has become a new alternative in the treatment of SAA [19]. In the original reports ALG was followed by a BM infusion from a family donor [12, 15]. In subsequent experimental and clinical trials ALG has been effective with and without BM infusion [16, 17, 19, 20, 21]. This modality is applicable in the HLA-nonidentical setting; it is not followed by GvHD and leads to autologous BM recovery in more than 50% of patients with SAA. It is still an unsolved problem whether ALG followed by BM is more or less effective than ALG alone.