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Emphysema Quantification in Inflation-Fixed Lungs Using Low-Dose Computed Tomography and 3He Magnetic Resonance Imaging
- Source :
- Journal of Computer Assisted Tomography. 34:773-779
- Publication Year :
- 2010
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2010.
-
Abstract
- Objective: To evaluate the use of inflation-fixed lung tissue for emphysema quantification with CT and 3He MR diffusion imaging. Methods: Fourteen subjects representing a range of chronic obstructive pulmonary disease severity who underwent complete or lobar lung resection were studied. CT measurements of lung attenuation and MR measurements of the hyperpolarized 3He apparent diffusion coefficient (ADC) in resected specimens fixed in inflation with heated formalin vapor were compared with measurements obtained before fixation. Results: The mean CT emphysema index was 56% ± 17% before and 58% ± 19% after fixation (P=0.77;R=0.76). Index differences correlated with differences in lung volume (R2=0.47). The mean 3He ADC was 0.40 ± 0.15 cm2/sec before and 0.39 ± 0.14 cm2/sec after fixation (P=0.03, R=0.98). The CT emphysema index and the 3He ADC were correlated before (R=0.89) and after fixation (R=0.79). Conclusion: Concordance of CT and 3He MR imaging measurements in unfixed and inflation-fixed lungs supports the use of inflation-fixed lungs for quantitative imaging studies in emphysema.
- Subjects :
- medicine.medical_specialty
Lung
Quantitative imaging
medicine.diagnostic_test
business.industry
Low dose
Magnetic resonance imaging
Computed tomography
respiratory system
respiratory tract diseases
medicine.anatomical_structure
medicine
Effective diffusion coefficient
Radiology, Nuclear Medicine and imaging
Lung volumes
Radiology
business
Fixation (histology)
Subjects
Details
- ISSN :
- 03638715
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Journal of Computer Assisted Tomography
- Accession number :
- edsair.doi...........5605efce5fbf472fcc07f1f886980302