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It takes more than two to tango: Dishevelled polymerization and Wnt signaling
- Source :
- Nature Structural & Molecular Biology. 14:463-465
- Publication Year :
- 2007
- Publisher :
- Springer Science and Business Media LLC, 2007.
-
Abstract
- Wnt signaling has key roles in embryogenesis and oncogenesis, yet several aspects of Wnt signal transduction remain mysterious. Schwarz-Romond et al. demonstrate that the Wnt signaling protein Dishevelled has the surprising ability to form dynamic polymers and present evidence that polymerization is crucial in signaling, perhaps forming an inducible scaffold for further signal transduction.
Details
- ISSN :
- 15459985 and 15459993
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Nature Structural & Molecular Biology
- Accession number :
- edsair.doi...........55ed61079ba184202d186b7fe61a3255