Sulfaethylthiadiazole (SETD) Release from Synthetic Wax Prolonged-Release Particles I

Synthetic wax particles containing sulfaethylthiadiazole (SETD) dispersed throughout and on the surface were made by a method of aqueous dispersion using various concentrations of polysorbate 80 USP and sorbitan monooleate each alone and in combination as dispersants. The in vitro release of SETD from 50–70 mesh wax particles was investigated with a rotating bottle dissolution apparatus, using simulated gastric and intestinal fluids. The dispersant factor was found to affect both the release rate and the proportion of total drug apparently constituting the prolonged-release fraction.