138: Vitamin D Levels in Children With COVID-19 Admitted to the PICU

INTRODUCTION/HYPOTHESIS: Vitamin-D (Vit-D) has an important immunomodulatory role and its deficiency has been linked to increased viral respiratory infections in the pediatric population Recent adult studies have shown an association between lower Vit-D levels and mortality in COVID-19 Low Vit-D levels are common in children with obesity and associated with enhanced systemic inflammation METHODS: This is an IRB approved, retrospective case series of children with COVID-19 admitted to a tertiary pediatric intensive care unit (PICU), describing the clinical features and 25-hydroxy-Vit-D levels Charts were reviewed and pertinent data collected Deidentified data were analyzed using SPSS v 26 Categorical data are presented as frequencies and percentages Continuous data presented as median with interquartile range (IQR) RESULTS: A total of 14 COVID-19 patients who had 25- OH Vit D levels measured were reviewed All patients had MIS-C (fever, inflammation, and 2 or more organ involvement) Demographic data included, females 50% (n=7), Hispanics 64 3% (n=9), whites 78 6% (n=11), and blacks, 21 4% (n=3) The median age was 15 (IQR 4 83) with 64% (n=9) teens Overweight or obese was present in 71 4% (n=10) Median BMI was 31 2 (IQR18 31) Vit-D deficiency (level