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GLUCAGON LIKE PEPTIDE-1 REDUCES RAISED INTRACRANIAL PRESSURE
- Source :
- Journal of Neurology, Neurosurgery & Psychiatry. 87:e1.211-e1
- Publication Year :
- 2016
- Publisher :
- BMJ, 2016.
-
Abstract
- Current therapies for reducing raised intracranial pressure (ICP) in conditions such as idiopathic intracranial hypertension (IIH) have limited efficacy and tolerability; therefore there is an urgent need to develop novel therapies. Glucagon-like peptide-1 receptor (GLP-1R) agonists are used therapeutically to treat diabetes and promote weight loss but have also been shown to affect fluid homeostasis in the kidney. The GLP-1R is also present in the choroid plexus, therefore we investigated whether Exendin-4, a GLP-1R agonist, is able to modulate cerebrospinal fluid (CSF) secretion at the choroid plexus and subsequently reduce ICP. We used in vitro models of the choroid plexus to demonstrate the presence of the GLP-1R and, after Exendin-4 treatment, showed a two fold increase in cAMP, a downstream signaling molecule. We also determine that treatment with Exendin-4 reduces Na+ K+ ATPase activity, a key regulator of CSF secretion. Finally, we demonstrate that administration of Exendin-4 in normal and raised ICP (hydrocephalic) rats significantly reduces ICP. These findings provide the first proof of concept that GLP-1R agonists can affect CSF secretion and ICP. Repurposing existing GLP-1 drugs may represent a novel therapeutic strategy for conditions of raised ICP including IIH, hydrocephalus and traumatic brain injury.
- Subjects :
- Agonist
endocrine system
Kidney
medicine.drug_class
business.industry
Traumatic brain injury
digestive, oral, and skin physiology
Pharmacology
medicine.disease
Glucagon-like peptide-1
Hydrocephalus
Psychiatry and Mental health
Cerebrospinal fluid
medicine.anatomical_structure
Anesthesia
medicine
Surgery
Choroid plexus
Neurology (clinical)
Receptor
business
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 1468330X and 00223050
- Volume :
- 87
- Database :
- OpenAIRE
- Journal :
- Journal of Neurology, Neurosurgery & Psychiatry
- Accession number :
- edsair.doi...........549dcfe0e2f71c509f50830244ae89e6