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Synthesis and Antitumor Activity of 2-N-,3-S-Substituted 5-(4-Benzyloxyphenyl)-1,2,4-Triazoles
- Source :
- Pharmaceutical Chemistry Journal. 51:760-763
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Cyclization of substituted thiosemicarbazides in alkaline medium was used to synthesize the corresponding 3-thio-4-benzyl(cyclohexyl, allyl)-5-(4-benzyloxyphenyl)-1,2,4-triazoles. These compounds were 3-S-alkylated with ethylene chlorohydrin, chloroacetamide, 3-bromo-4-methoxybenzyl chloride, and chloroacetic, 2-bromopropionic, and 2-bromocaproic acids. Aminomethylation and oxymethylation reactions were studied. 2-N-Aminomethylene and 2-N-oxymethylenetriazoline-3-thiones were prepared. The antitumor activity of the compounds synthesized here were studied.
- Subjects :
- Pharmacology
Antitumor activity
010405 organic chemistry
Chemistry
Pharmacology toxicology
Ethylene chlorohydrin
01 natural sciences
Chloride
0104 chemical sciences
010404 medicinal & biomolecular chemistry
chemistry.chemical_compound
Drug Discovery
medicine
Organic chemistry
Chloroacetamide
medicine.drug
Subjects
Details
- ISSN :
- 15739031 and 0091150X
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Pharmaceutical Chemistry Journal
- Accession number :
- edsair.doi...........54881f775094bbb1a3ca71cf5f67dda9