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An efficient synthesis of 1′,4′-dihydro-2′H-spiro[azetidin-2,3′-quinolin]-2′-one
- Source :
- Research on Chemical Intermediates. 43:219-228
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- A facile synthesis of 1′,4′-dihydro-2′H-spiro[azetidin-2,3′-quinolin]-2′-one is described. Synthetic highlights include simultaneous construction of azetidine ring by intramolecular alkylation and formation of spirocarbon center in excellent yield plus removal of p-methoxybenzyl (PMB) amide protective group in mild condition with good yield.
Details
- ISSN :
- 15685675 and 09226168
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Research on Chemical Intermediates
- Accession number :
- edsair.doi...........545ace70c004cbbe8284eb484447d987