Surface-enhanced Raman scattering chemosensing of proteins

Changes in protein expression levels and protein structure may be related to some diseases. Thus the precise quantification and characterization of proteins is already used for the disease diagnosis. Compared with several other alternative methods, indirect surface-enhanced Raman scattering (SERS) spectroscopy, aided by the use of chemosensors with high affinity and selectivity for the target protein, is regarded as an excellent choice for the quantification and structural characterization of biopolymers. Herein, we review the main advance of using plasmonic nanostructures combined with chemosensors as SERS sensing platforms for the detection and quantification of proteins.