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Layered double hydroxide as novel antibacterial drug delivery system
- Source :
- Journal of Physics and Chemistry of Solids. 71:685-688
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- The cephalosporin class antibacterial agent, cefazolin, was intercalated into layered double hydroxides (LDHs) in order to improve the drug efficiency as well as to achieve the controlled release property. Cefazolin molecules were incorporated into LDH through conventional ion exchange reaction. X-ray diffraction pattern analyses confirmed that cefazolin molecules were intercalated between the interlayer spaces of LDH. Fourier-transform infrared spectra and high performance liquid chromatographs clearly showed that the drug molecules were stabilized in LDH lattice through electrostatic interaction and released without any changes in their chemical integrity. Antibacterial activity of the cefazolin-LDH nanohybrid was also examined by an in vitro test, such as the minimal inhibitory concentration (MIC) by dilution method. Consequently, the cefazolin-LDH nanohybrid revealed an enhanced antibacterial activity compared to the cefazolin itself not only due to an improvement of chemical stability of cefazolin molecules but also due to a controlled release property.
- Subjects :
- Ion exchange
Chemistry
organic chemicals
Cefazolin
Layered double hydroxides
Analytical chemistry
General Chemistry
biochemical phenomena, metabolism, and nutrition
engineering.material
bacterial infections and mycoses
Condensed Matter Physics
Controlled release
chemistry.chemical_compound
polycyclic compounds
medicine
engineering
Hydroxide
General Materials Science
Chemical stability
Antibacterial activity
Antibacterial agent
medicine.drug
Nuclear chemistry
Subjects
Details
- ISSN :
- 00223697
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- Journal of Physics and Chemistry of Solids
- Accession number :
- edsair.doi...........53a0a32fa33b2061426647632b2f6474