Cyclophosphamide

At the Mayo Clinic from May 1960, through December 1965, 138 patients with recurrent and metastatic ovarian cancer were treated with cancer chemotherapy. Of these, 106 patients had tumors that were considered to be unequivocally ovarian in origin. Of the 106 patients, 82 were treated with cyclophosphamide, with and without radiation; 17 of these had objective remission and 8 had arrest of progress of the tumor. Thus, 23.6 per cent obtained significant palliation. Toxicity of the compound was moderate. No cures resulted from the therapy. Continued investigation of treatment regimens and comparison with other compounds are contemplated.