Synthesis and Anion Recognition of Cholic Acid-based Tripodal Receptor: A Chloride Selective Anion Receptor

Synthesis of cholic acid-based tripodal receptor (1) and its high chloride ion affinity in comparison with that of chenodeoxycholic acid (2) and lithocholic acid-based receptor (3) was achieved. Anion binding affinities of the receptors were evaluated NMR and ITC titrations. Tripodal receptor 1 showed a selective affinity for over , , , and . The selectivity of 1 for is about 3 times that of , and 17 times that for .