SCN5A MUTATION INCREASES THE RISK OF MAJOR ARRHYTHMIC EVENTS IN BRUGADA SYNDROME: SYSTEMATIC REVIEW AND META-ANALYSIS

Brugada syndrome (BrS) is an autosomal dominant inherited arrhythmic disease associated with the SCN5A mutation. Recent studies suggest that SCN5A mutation is associated with major arrhythmic events (MAE) in BrS which is controversial in previous studies. However, a systematic review and meta