Switch from NPH Human Insulin to Insulin Glargine Improves Glycemic Control and Frequency of Hypoglycemia in Japanese Patients with Type 1 Diabetes Mellitus

To evaluate the effects of switching from NPH insulin(twice daily)to insulin glargine on blood glucose control(HbA1C),insulin dosage and frequency of hypoglycemia in Japanese patients with type 1 diabetes,we monitored these parameters in 37 type 1 diabetics for 12 months after switching.The patients were assigned to 3 groups according to HbA1C at switching :good(