Back to Search
Start Over
Control of organic polymorph formation: crystallization pathways in acoustically levitated droplets
- Source :
- Zeitschrift für Kristallographie - Crystalline Materials. 232:15-24
- Publication Year :
- 2016
- Publisher :
- Walter de Gruyter GmbH, 2016.
-
Abstract
- Theoretical and experimental studies indicate that crystal nucleation can take more complex pathways than expected on the ground of the classical nucleation theory. Among these pathways are the formation of pre-nucleation clusters and amorphous precursor phases. A direct in situ observation of the different pathways of nucleation from solution is challenging since the paths can be influenced by heterogeneous nucleation sites, such as container walls. Here, we provide insights into the crystallization process using the in situ combination of an acoustic levitator, Raman spectroscopy, and X-ray scattering. The contactless sample holder enables the observation of homogeneous crystallization processes and the detection of intermediates and final crystalline forms. We provide evidence for the existence of multiple pathways of nucleation based on the investigation of the crystallization of organic molecules from different solvents. Starting from a diluted solution, a supersaturation is reached during the experiment due to the evaporation of the solvent. The highly supersaturated solution reveals different pathways of crystallization. Depending on the degree of supersaturation either the thermodynamically stable or the metastable crystal form is observed.
- Subjects :
- Materials science
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
01 natural sciences
0104 chemical sciences
law.invention
Inorganic Chemistry
symbols.namesake
Chemical engineering
Polymorphism (materials science)
law
Polyamorphism
symbols
General Materials Science
Crystallization
0210 nano-technology
Raman spectroscopy
Subjects
Details
- ISSN :
- 21967105 and 21944946
- Volume :
- 232
- Database :
- OpenAIRE
- Journal :
- Zeitschrift für Kristallographie - Crystalline Materials
- Accession number :
- edsair.doi...........52b63e97e76c9c1039be8b167df73926