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Kutane Nebenwirkungen einer EGF-Rezeptor-Blockade und deren Management
- Source :
- Der Hautarzt. 57:509-513
- Publication Year :
- 2006
- Publisher :
- Springer Science and Business Media LLC, 2006.
-
Abstract
- The receptor of the epidermal growth factor (EGF-receptor) plays a role in the pathogenesis of many human carcinomas. Recent strategies in anti-tumor therapy target the EGF-receptor, e.g., by the EGF-receptor blocking monoclonal antibody cetuximab or by small molecules inhibiting the tyrosine kinase activity of the EGF-receptor, such as gefitinib and erlotinib. The EGF-receptor is also expressed in normal human skin; in clinical trials with different EGF-receptor inhibitors, cutaneous side effects were common. We report on cutaneous side effects of EGF-receptor blockade, in particular acneiform lesions, xerosis and paronychia, and discuss their management.
- Subjects :
- Cetuximab
biology
business.industry
Dermatology
Blockade
Gefitinib
Epidermal growth factor
Immunology
Cancer research
biology.protein
Medicine
Epidermal growth factor receptor
Erlotinib
business
Erlotinib Hydrochloride
Tyrosine kinase
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- ISSN :
- 14321173 and 00178470
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Der Hautarzt
- Accession number :
- edsair.doi...........524d149572130951c21b3ee3b9ebf5d8
- Full Text :
- https://doi.org/10.1007/s00105-005-1033-3