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Kutane Nebenwirkungen einer EGF-Rezeptor-Blockade und deren Management

Authors :
T. Werfel
Jörn Elsner
Alexander Kapp
Ralf Gutzmer
Source :
Der Hautarzt. 57:509-513
Publication Year :
2006
Publisher :
Springer Science and Business Media LLC, 2006.

Abstract

The receptor of the epidermal growth factor (EGF-receptor) plays a role in the pathogenesis of many human carcinomas. Recent strategies in anti-tumor therapy target the EGF-receptor, e.g., by the EGF-receptor blocking monoclonal antibody cetuximab or by small molecules inhibiting the tyrosine kinase activity of the EGF-receptor, such as gefitinib and erlotinib. The EGF-receptor is also expressed in normal human skin; in clinical trials with different EGF-receptor inhibitors, cutaneous side effects were common. We report on cutaneous side effects of EGF-receptor blockade, in particular acneiform lesions, xerosis and paronychia, and discuss their management.

Details

ISSN :
14321173 and 00178470
Volume :
57
Database :
OpenAIRE
Journal :
Der Hautarzt
Accession number :
edsair.doi...........524d149572130951c21b3ee3b9ebf5d8
Full Text :
https://doi.org/10.1007/s00105-005-1033-3