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Peri-prostatic adipose tissue measurements using MRI predict prostate cancer aggressiveness in men undergoing radical prostatectomy
- Source :
- Journal of Endocrinological Investigation. 44:287-296
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- To evaluate the effect of peri-prostatic adipose tissue (PPAT) measurements using preoperative MRI on the prediction of prostate cancer (PCa) aggressiveness in men undergoing radical prostatectomy (RP). We performed a retrospective study on 179 consecutive patients receiving RP from June 2016 to October 2018. Clinical characteristics were collected. PPAT measurements including peri-prostatic fat area (PPFA) and peri-prostatic fat area to prostate area (PA) ratio (PPFA/PA) were calculated by MRI. Multivariable logistic regression analysis was performed to identify independent predictors of PCa lymph node metastasis (LNM). The predictive performance was estimated through ROC curves. Nomograms were created based on the predictors. Pathologic Gleason score positively correlated with digital rectal examination (DRE), PSA, PPFA/PA, P504S, and Ki-67 (all P
- Subjects :
- medicine.medical_specialty
Receiver operating characteristic
medicine.diagnostic_test
Prostatectomy
business.industry
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Urology
030209 endocrinology & metabolism
Retrospective cohort study
Rectal examination
Nomogram
urologic and male genital diseases
medicine.disease
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Endocrinology
medicine.anatomical_structure
Prostate
030220 oncology & carcinogenesis
medicine
Stage (cooking)
business
Subjects
Details
- ISSN :
- 17208386
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Journal of Endocrinological Investigation
- Accession number :
- edsair.doi...........5221d0810e107bb359da3452d974ce50