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Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
- Publisher :
- The University of North Carolina at Chapel Hill University Libraries
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Abstract
- Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality1. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation2,3, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P
- Subjects :
- 2. Zero hunger
10. No inequality
3. Good health
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi...........51e7a0d801f8247d3954d97de317cb9f