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Long-term effect of cataract phacoemulsification on the inflammation control and clinical outcome in uveitis patients

Long-term effect of cataract phacoemulsification on the inflammation control and clinical outcome in uveitis patients

Authors :
Oren Tomkins-Netzer
Lazha Sharief
Susan Lightman
Julijana Baltinas
Source :
Clinical & Experimental Ophthalmology. 46:1048-1054
Publication Year :
2018
Publisher :
Wiley, 2018.

Abstract

IMPORTANCE Cataract is one of the most common complications associated with uveitis, and is the leading cause of vision loss in these patients. BACKGROUND The study aimed to evaluate the effect of phacoemulsification on the long-term clinical outcome and inflammation control in uveitis patients. DESIGN Longitudinal study. PARTICIPANTS Of 1907 eyes with uveitis, 309 eyes underwent phacoemulsification were compared to a control group of 300 phakic eyes with uveitis. METHOD The risk of vision loss and macular oedema in pseudophakic eyes were compared to the phakic group. The rates of corticosteroids administration and uveitis relapse were also measured in pseudophakic eyes and compared to preoperative period. MAIN OUTCOME MEASURES Change in uveitis activity post phacoemulsification by measuring rate of uveitis relapse and use of topical and systemic steroids. Also, to measure the risk of vision loss and macular oedema post surgery. RESULTS Over a median follow-up time of 6.7 years or 2249 eye-years (EY), pseudophakic eyes had a greater risk of vision loss (hazard ratio [HR] 2.4, CI 1.4 to 4.0; P 7.5 mg/day. CONCLUSIONS AND RELEVANCE There was no significant increase in uveitis relapse rate post-phacoemulsification with the use of current prophylactic inflammation control measures.

Details

ISSN :
14426404
Volume :
46
Database :
OpenAIRE
Journal :
Clinical & Experimental Ophthalmology
Accession number :
edsair.doi...........5188102d57876b0f91fb2b9c71990e64
Full Text :
https://doi.org/10.1111/ceo.13369