1-Formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (1-CHO–DHP)–Cysteine Conjugates: Metabolic Formation and Binding to Cellular DNA

Authors :: Qingsu Xia
Peter P. Fu
Yuewei Zhao
Xiaobo He
Source :: Chemical Research in Toxicology. 33:2139-2146
Publication Year :: 2020
Publisher :: American Chemical Society (ACS), 2020.
Abstract: 1-Formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (1-CHO-DHP) is a potential proximate carcinogenic metabolite of pyrrolizidine alkaloids. In the present study, we determined that reaction of 1-CHO-DHP...

Subjects :: endocrine system
0303 health sciences
Chemistry
Metabolite
General Medicine
010501 environmental sciences
Toxicology
01 natural sciences
03 medical and health sciences
chemistry.chemical_compound
Biochemistry
Cellular dna
Pyrrolizidine
heterocyclic compounds
Carcinogen
030304 developmental biology
0105 earth and related environmental sciences
Conjugate
Cysteine

Full Text Access

Tools