The paradigmatic shift in the clinical profile of dengue patients: a prospective observational study from a tertiary care center in north India

Introduction: In head and neck cancer the location, size, shape of disease, and normal anatomy change in 6-7 weeks radiotherapy. As a result, steep dose gradients move across target and critical structures resulting in underdose to target and overdose to critical structures. Aim: comparison of target coverage in initial IMRT plan and replan and to quantify dose changes to normal structures in two plans. Methods and Material: 30 patients with locally advanced head and neck cancer patients planned for curative radiotherapy were selected and treated with 3DCRT plan. For dosimetric comparison IMRT plan was created for pre-treatment and repeat CT, which was done after 40Gy. Statistical analysis used: Statistical methods (student’s paired t-test) were applied. Results: Both PTV coverage (V95 from 96.29±1.12 to 97.33±0.80) and dose (D95 from 66.64±0.87 to 67.57±0.74) increased in replanned CT. Both max and mean doses to the brainstem and spinal cord along with mean dose to parotid glands increased in replanned CT. Conclusions: Replanning is necessary during mid-treatment to accommodate anatomical and dosimetric changes during curative radiotherapy.