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Ovarian dysfunction after ischemia-reperfusion of the ovarian blood vessel in experimental rats
- Source :
- Reproductive Immunology and Biology. 24:77-80
- Publication Year :
- 2009
- Publisher :
- Japan Society for Immunology of Reproduction, 2009.
-
Abstract
- Excessive production of reactive oxygen species (ROS) lead to oxidative stress in tissue or organ dysfunction. To confirm ovarian dysfunction by ROS, ischemia-reperfusion (I/R) treatment of the ovarian blood vessels was performed using experimental rats in this study. Preventive effect of superoxide dismutase (SOD) as a radical scavenger against ovarian I/R injury was also examined. Hormonal sensitivities to equine chorionic gonadotropin (eCG) and human chorionic gonadotropin (hCG) in the ovary decreased after the I/R. Ovarian tissue and ovum destruction were also observed. These changes could be prevented by SOD administration. Our data suggest that I/R injury related to ROS production causes ovarian dysfunction. The dysfunction is prevented by administration of a radical scavenger.
- Subjects :
- endocrine system
Organizational Behavior and Human Resource Management
medicine.medical_specialty
Strategy and Management
Ischemia
Pharmaceutical Science
Ovary
Biology
medicine.disease_cause
Superoxide dismutase
Internal medicine
Drug Discovery
medicine
Equine chorionic gonadotropin
Marketing
Pharmacology
chemistry.chemical_classification
Reactive oxygen species
Organ dysfunction
medicine.disease
Endocrinology
medicine.anatomical_structure
chemistry
biology.protein
medicine.symptom
Oxidative stress
Blood vessel
Subjects
Details
- ISSN :
- 18817211 and 1881607X
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Reproductive Immunology and Biology
- Accession number :
- edsair.doi...........509600e3fc6308a70f995ccdc30fd378