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Isoniazid Derived Schiff Base Metal Complexes: Synthesis, Characterization, Thermal Stability, Antibacterial and Antioxidant Activity Study

Authors :
Md. Kudrat-E- Zahan
Laila Arjuman Banu
Md. Nazrul Islam
Md. Ashrafuzzaman
Farzana Khanm Camellia
Source :
Asian Journal of Chemical Sciences. :23-36
Publication Year :
2022
Publisher :
Sciencedomain International, 2022.

Abstract

Transition metal complexes of Cu2+, Ni2+ and Co2+ with the Schiff base ligand, N-(2-methoxybenzylidene)isonicotinohydrazone, (L1) were synthesized by the conventional condensation approach. Ligand and its metal were characterized by FT-IR, UV-Vis, Magnetic moment measurements and Thermogravimetric (TGA) analysis. IR spectra revealed that the Schiff base ligand coordinated to the metal ion through nitrogen (N) of azomethine group and oxygen (O) of carbonyl group. IR data coupled with TGA analysis confirmed the presence of coordinated water molecules. Antibacterial activity for both ligand and its complexes were investigated against some pathogenic bacteria and the best activity was observed in the case of the CuL1 against E. coli when compared with standard drug, Kanamycin-30. The antioxidant activity of the CuL1 complex was the greatest among all the complexes when compared to that of BHT.

Details

ISSN :
24567795
Database :
OpenAIRE
Journal :
Asian Journal of Chemical Sciences
Accession number :
edsair.doi...........50299cb8eca4bb533a57375065d8b7a2
Full Text :
https://doi.org/10.9734/ajocs/2022/v11i419131