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Predictive In Vitro Vitreous and Serum Models and Methods to Assess Thiol-Related Quality Attributes in Protein Therapeutics

Authors :
Chen Yan
Feng Yang
Christopher Yu
George Tsui
Y. Diana Liu
Bingchuan Wei
Christopher Cornell
Source :
Analytical Chemistry. 92:6869-6876
Publication Year :
2020
Publisher :
American Chemical Society (ACS), 2020.

Abstract

In vitro models that mimic the in vivo environment can greatly facilitate and support criticality assessment of product quality attributes for therapeutic drugs to ensure product quality. An in vit...

Details

ISSN :
15206882 and 00032700
Volume :
92
Database :
OpenAIRE
Journal :
Analytical Chemistry
Accession number :
edsair.doi...........4f9fd8036a1829703917c4df62c16e60