Back to Search
Start Over
Novel purine conjugates with N-heterocycles: synthesis and anti-influenza activity
- Source :
- Chemistry of Heterocyclic Compounds. 57:498-504
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- A number of novel amides were synthesized by coupling of 6-[(9H-purin-6-yl)amino]hexanoic acid to heterocyclic amines. The antiviral activity of the obtained compounds, as well as of purine conjugates in which 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine is linked to position 6 of purine through a fragment of ω-amino acids with varying lengths of polymethylene chains against influenza A and B viruses was studied in vitro. Purine derivatives have been shown to have moderate activity against influenza A (H1N1) virus. The antiinfluenza activity and cytotoxicity of conjugates with 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine depend on the length of the linker fragment.
Details
- ISSN :
- 15738353 and 00093122
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Chemistry of Heterocyclic Compounds
- Accession number :
- edsair.doi...........4f6be682ee614a7b4fa09a91f86c9c0f