Efficient Bakers’ Yeast-Catalyzed Multicomponent Synthesis of <font>α</font>-Aminophosphonates in One Pot

Utilizing bakers’ yeast (Saccharomyces cerevisiae) as a biocatalyst, synthesis of α-aminophosphonates in one pot has been accomplished by the three-component reaction of an aldehyde, an amine, and diethyl phosphite in moderate to good yields under solvent-free reaction conditions. Supplemental materials are available for this article. Go to the publisher&#39;s online edition of Synthetic Communications&#174; to view the free supplemental file.