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A high prevalence of antibody to the hepatitis C virus in patients with hepatocellular carcinoma in Japan
- Source :
- Cancer. 67:429-433
- Publication Year :
- 1991
- Publisher :
- Wiley, 1991.
-
Abstract
- In Japan, hepatocellular carcinoma (HCC) is one of the most prevalent cancers, with a reported fatality rate showing a consistent and significant increase in the last decade. At most, only 25% of HCC cases are positive for the hepatitis B surface antigen (HBsAg). To investigate a potential role for hepatitis C virus (HCV) in the development of HCC, sera from 105 HBsAg-negative HCC patients were collected from five districts of Japan and assayed for antibody to HCV antigen (HCVAb). A large number of these patients (76.2%) were found to be positive for the HCVAb in comparison with the reported prevalence in sera from blood donors (1.1%). A history of blood transfusion was found in 39.6% of the cases positive for HCVAb, which was significantly different to the lower rate (4.7%) observed in HCC patients who were both positive for HBsAg and negative for HCVAb (P less than 0.001).
- Subjects :
- Cancer Research
HBsAg
Blood transfusion
biology
business.industry
medicine.medical_treatment
Hepatitis C virus
medicine.disease
medicine.disease_cause
Virology
digestive system diseases
Oncology
Antigen
Hepatocellular carcinoma
Case fatality rate
biology.protein
medicine
In patient
Antibody
business
Subjects
Details
- ISSN :
- 10970142 and 0008543X
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Cancer
- Accession number :
- edsair.doi...........4f46c5dcb3b1c0035d0813e6bc1480ff
- Full Text :
- https://doi.org/10.1002/1097-0142(19910115)67:2<429::aid-cncr2820670218>3.0.co;2-#