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Photothérapie dynamique des hémangiomes choroïdiens
- Source :
- Journal Français d'Ophtalmologie. 29:1013-1017
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Purpose: To evaluate the safety and efficacy of photodynamic therapy in the management of symptomatic circumscribed choroidal hemangiomas (CCH) with exudative activity. Patients and Methods: This prospective nonrandomized study included eight patients referred to us for management of CCH with exudative activity. PDT was applied by diode laser (689nm) with a light dose of 100J/cm(2) and using verteporfin (6mg/m(2)) IV bolus injection. The treatment spot diameter accurately corresponded to the tumor basal diameter (TBD). Results: The mean tumor thickness before PDT was 3.3 mm (range, 2.7-7.5 mm) and the mean largest TBD was 6.1 mm (range, 5-12mm). All patients were managed with a single PDT application. After a mean follow-up of 24.2 months (range, 17-29 months), all CCH (100%) showed regression of tumor thickness and complete resorption of the serous retinal fluid; 87.5% of the patients showed a flat tumor scar. All CCH showed overlying PDT-related retinal pigmented epithelium atrophic changes. No case of retinal vascular occlusion or recurrent leakage was documented. Five patients (62.5%) showed visual improvement, one (12.5%) retained stable vision and two (25%) developed worse vision due to chronic exudation-related RPE changes in one patient and preretinal fibrosis in another. Conclusion: PDT using verteporfin offers a safe and effective therapeutic option to manage CCH. Complete resorption of subretinal fluid is usually associated with visual improvement.
- Subjects :
- Retinal Vascular Occlusion
medicine.medical_specialty
business.industry
medicine.medical_treatment
Retinal
Photodynamic therapy
Verteporfin
eye diseases
Surgery
Resorption
Preretinal fibrosis
Ophthalmology
chemistry.chemical_compound
Serous fluid
chemistry
medicine
Pigmented Epithelium
business
Nuclear medicine
medicine.drug
Subjects
Details
- ISSN :
- 01815512
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Journal Français d'Ophtalmologie
- Accession number :
- edsair.doi...........4f389a84df3285f2e3bf6cbb9284a19f