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Biomaterials-based immunomodulation enhances survival of murine vascularized composite allografts

Authors :
Sven D. Sommerfeld
Xianyu Zhou
Joscelyn C. Mejías
Byoung Chol Oh
David R. Maestas
Georg J. Furtmüller
Philippe A. Laffont
Jennifer H. Elisseeff
Gerald Brandacher
Source :
Biomaterials Science.
Publication Year :
2023
Publisher :
Royal Society of Chemistry (RSC), 2023.

Abstract

ECM biomaterial implanted at the wound interface during a mouse hind limb allograft transplant improves allograft tolerance by working synergistically with costimulatory blockade (CTLA4-Ig) to modulate the local immune response.

Details

ISSN :
20474849 and 20474830
Database :
OpenAIRE
Journal :
Biomaterials Science
Accession number :
edsair.doi...........4f2d2f87bf79cffe7faf91e8c4ae21e2