Lignans and coumarins metabolites from Melicopehayesii

Two novel compounds, the lignan, (+)-2- (3,4-dimethoxyphenyl)-6-(3,4-dihydroxyphenyl)-3,7-dioxabicyclo [3,3,0]octane, and the coumarin, (+)-7-(3-methyl-4-carboxybutanoxy)umbelliferone methyl ester, have been isolated from the aerialparts of Melicope hayesii . The known compounds, eudesmin, kobusin, N - p -coumaroyltyramine, N -methyl-2-pyrrolidinone, umbelliferone and 7- (3-methylbut-2-enoxy)umbelliferone were alsoobtained. Their structures were determined by extensive NMR studies.