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Cellular adhesion and proliferation on poly(3,4-ethylenedioxythiophene): Benefits in the electroactivity of the conducting polymer
- Source :
- European Polymer Journal. 43:2342-2349
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- Cell adhesion and proliferation in poly(3,4-ethylenedioxythiophene), an electroactive polythiophene derivative generated by anodic polymerization, has been investigated. Results show that epithelial cells Hep-2 present significant activity on the surface of poly(3,4-ethylenedioxythiophene) electrodeposited on stainless steel electrodes, no sign of cytotoxicity being detected for this conducting polymer. Indeed, seeded and cultured cells bound better to poly(3,4-ethylenedioxythiophene) than to uncoated stainless steel, the latter substrate being used as a control. Furthermore, the electrochemical characteristics of poly(3,4-ethylenedioxythiophene) covered with cells was determined in different biological media using cyclic voltammetry experiments. Results reveal a significant increase in the electroactivity of this material when it is covered with a cellular monolayer. The overall of the results evidences not only the biocompatibility of poly(3,4-ethylenedioxythiophene) with Hep-2 cells but also their electrocompatibility.
- Subjects :
- Conductive polymer
Materials science
Polymers and Plastics
Biocompatibility
Organic Chemistry
General Physics and Astronomy
Adhesion
chemistry.chemical_compound
Chemical engineering
chemistry
Polymerization
Monolayer
Polymer chemistry
Materials Chemistry
Cyclic voltammetry
Cell adhesion
Poly(3,4-ethylenedioxythiophene)
Subjects
Details
- ISSN :
- 00143057
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- European Polymer Journal
- Accession number :
- edsair.doi...........4e5a5a691cc75dfb610d89a40d59b34f