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BALB/c mice resistant to Toxoplasma gondii infection proved to be highly susceptible when previously infected with Myocoptes musculinus fur mites

Authors :
Eloisa Amália Vieira Ferro
Deise A. O. Silva
Neide M. Silva
José Roberto Mineo
Maria Cristina Roque-Barreira
Áurea Welter
Elaine Vicente Lourenço
Source :
International Journal of Experimental Pathology. 88:325-335
Publication Year :
2007
Publisher :
Wiley, 2007.

Abstract

Summary The immune response induced by Toxoplasma gondii is characterized by Th1 immune mechanisms. We previously demonstrated that C57BL/6 mice infested with Myocoptes musculinus and infected with T. gondii by intraperitoneal route undergo accelerated mortality according to Th2 immune mechanisms induced by the acarian. To evaluate whether infection with M. musculinus influences T. gondii-induced Th1 response in a resistant mouse lineage, BALB/c, which develops latent chronic toxoplasmosis in a way similar to that observed in immunocompetent humans, this study was done. The animals were infected with T. gondii ME-49 strain 1 month after M. musculinus infestation, being the survival and the immune response monitored. The double-infected displayed higher mortality rate if compared with the mono-infected mice. In addition, infection with M. musculinus changed the T. gondii-specific immune response, converting BALB/c host to a susceptible phenotype. Spleen cells had increased the levels of IL-4 in double-infected mice. This alteration was associated with severe pneumonia, encephalitis and wasting condition. In addition, a higher tissue parasitism was observed in double-infected animals. It can be concluded that infection with these two contrasting parasites, M. musculinus and T. gondii, may convert an immunocompetent host into a susceptible one, and such a host will develop severe toxoplasmosis.

Details

ISSN :
09599673
Volume :
88
Database :
OpenAIRE
Journal :
International Journal of Experimental Pathology
Accession number :
edsair.doi...........4e2b9adb4ffb4cabb19bd334edc7d565
Full Text :
https://doi.org/10.1111/j.1365-2613.2007.00534.x