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GW24-e2303 Relationship between asymmetric dimethylarginine and carotid atherosclerosis in patients with essential hypertension
- Source :
- Heart. 99:A200.2-A200
- Publication Year :
- 2013
- Publisher :
- BMJ, 2013.
-
Abstract
- Objectives Circulating levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are increased in hypertensive patients. This study was to assess the relationship between plasma ADMA level and carotid atherosclerosis in patients with essential hypertension. Methods A total of 182 individuals with never-treated essential hypertension and 182 age-matched healthy controls were studied. All study subjects were examined by B-mode ultrasound to measure the intima–media thickness (IMT) and plaque score in the carotid artery. Results Plasma ADMA levels, mean IMT, and plaque score were significantly greater in hypertensive patients than normotensive controls. In all subjects, plasma ADMA was positively correlated with mean IMT (r = 0.44, p Conclusions Our results suggest that increased levels of ADMA are associated with the development of carotid atherosclerosis in hypertensive patients.
- Subjects :
- Carotid atherosclerosis
medicine.medical_specialty
business.industry
Carotid arteries
Essential hypertension
medicine.disease
chemistry.chemical_compound
chemistry
Internal medicine
cardiovascular system
medicine
Cardiology
Endogenous nitric oxide
In patient
cardiovascular diseases
Cardiology and Cardiovascular Medicine
Asymmetric dimethylarginine
business
Subjects
Details
- ISSN :
- 1468201X and 13556037
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Heart
- Accession number :
- edsair.doi...........4deb3fc20ffa1712a18487fbbefe4459