Molar solubility of felodipine in different aqueous systems

The molar solubility of felodipine in water was calculated and experimentally determined. A polyoxyethylene-polyoxypropylene block copolymer (Synperonic T304) and sodium lauryl sulfate as surfactants and ethanol as cosolvent were used as solubilizing agents. Significantly different molar solubilities were determined for felodipine according to the approach used to achieve solubilization. Such differences are the result of the different mechanisms of solubilization of the additives.