A Comparison of the Pharmacological Effects of Some Compounds Related to 2-Aminoethylisothiuronium Bromide Hydrobromide (AET)

The pharmacological properties of nine compounds formed by substitutions either in the AET or in the APT molecule were studied in cats. None of the compounds elicited the chemoreflex characteristic of the parent compounds. In general, substitutions in the APT and AET molecules attenuated gut responses, amplified ganglionic block, ing activity (particularly in AET analogs), and resulted in compounds with some degree of neuromuscular depressant activity.