Comparison of 70 Gy 3DCRT with Concurrent Chemotherapy versus Conventional 66 Gy Radiotherapy with Concurrent Chemotherapy in Locally Advanced Squamous Cell Carcinoma of Larynx

Background: Laryngeal cancer is the most common malignancies of head neck region. The search for optimal treatment option for locally advanced laryngeal cancer is on throughout the world. Methodology: This was a prospective quasi experimental study carried out in the department of Radiation Oncology of NICRH, Dhaka and Square Hospitals Limited, Dhaka from July 2013 to May 2014. Result: Thirty patients each were accrued to arm A and arm B purposively to receive 3DCRT and conventional radiotherapy respectively. The patients age ranged from 30 to 60 years; 61.7% patients were male. Among the total patient 43.3% patients were in stage III and 56.7% patients in stage IVA. All radiation related toxicities were found significantly higher in 3DCRT arm (arm A) than conventional arm (arm B). Complete response was found in 40% patients in 3DCRT arm while in conventional arm it was only 10%. Partial response was 36.7% and 46.7% respectively. No response was seen in 8 patients, 3 in arm A and 5 in arm B. More patients in arm B (26.7%) were reported with progressive disease. Conclusion: It could be said from this study that three Dimensional 70 Gy Conformal Radiotherapy (3DCRT) with concurrent chemotherapy offers higher treatment outcome then conventional 2D radiotherapy with 66 Gy although which was statistically significant and toxicities were reported more in intervention group which need to be managed effectively.