Targeting glioma-initiating cells in GBM: ABTC-0904, a randomized phase 0/II study targeting the Sonic Hedgehog-signaling pathway

Authors :: Naoko Takebe
Amber E Kerstetter
Michael D. Prados
Xiaobu Ye
Kathleen R. Lamborn
Robert H. Miller
Jeffrey G. Supko
Andrew E. Sloan
Jeremy N. Rich
Stuart A. Grossman
Charles J. Nock
Source :: Journal of Clinical Oncology. 32:2026-2026
Publication Year :: 2014
Publisher :: American Society of Clinical Oncology (ASCO), 2014.
Abstract: 2026 Background: The prognosis for GBM, which appears to be driven by glioma initiating cells (GIC), remains poor. Our hypothesis was that interrupting sonic hedgehog signaling (SHh) would inhibit ...

Subjects :: Cancer Research
animal structures
Oncology
business.industry
Glioma
embryonic structures
Cancer research
medicine
Sonic hedgehog signaling pathway
medicine.disease
business
Hedgehog signaling pathway
nervous system diseases

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