Two metal complex derivatives of pyridine thiazole ligand: synthesis, characterization and biological activity

In this work, two new metal(II) complexes with ligand based on pyridine thiazolone group, [Zn(L)2(TsO)2]2DMF (1), {[Cd(L)(NO3)2H2O)]DMF}n (2) (where L = 4-(pyridin-4-yl)-2-(2-(pyridin-2- ylmethylene)hydrazinyl)thiazole), were prepared and characterized by physicochemical and spectroscopic methods. In addition, the structure of the complexes (1 and 2) was confirmed by single-crystal X-ray analysis. Complex 1 has a discrete monomeric structure where L acts as a bidentate agent coordinating the zinc(II) atom through pyridine nitrogen and thiazole nitrogen, while complex 2 consists of polymeric {[Cd(L)(NO3)2H2O)]DMF}n chains in which cadmium(II) atoms are linked by the bridging ligand. The in vitro antimicrobial and antitumor activities of the ligand and complexes (1 and 2) were evaluated against seven pathogenic bacterial strains and four human cancer cell lines, and the results showed that some compounds had absolute specificity for certain bacterial strains or cancer cell lines, which thus implied a good application prospect in pharmaceutical use.