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Photoredox-catalyzed stereoselective alkylation of enamides with N-hydroxyphthalimide esters via decarboxylative cross-coupling reactions
- Source :
- Chemical Science. 10:8792-8798
- Publication Year :
- 2019
- Publisher :
- Royal Society of Chemistry (RSC), 2019.
-
Abstract
- Stereoselective β-C(sp2)-H alkylation of enamides with redox-active N-hydroxyphthalimide esters via a photoredox-catalyzed decarboxylative cross-coupling reaction is demonstrated. This methodology features operational simplicity, broad substrate scopes, and excellent stereoselectivities and functional group tolerance, affording a diverse array of geometrically defined and synthetically valuable enamides bearing primary, secondary or tertiary alkyl groups in satisfactory yields.
- Subjects :
- chemistry.chemical_classification
010405 organic chemistry
Decarboxylative cross-coupling
Substrate (chemistry)
General Chemistry
N-hydroxyphthalimide
Alkylation
010402 general chemistry
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
Catalysis
chemistry.chemical_compound
chemistry
Functional group
Stereoselectivity
Alkyl
Subjects
Details
- ISSN :
- 20416539 and 20416520
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Chemical Science
- Accession number :
- edsair.doi...........4cce8e8abd4191888c98761e9114f81a