Back to Search Start Over

The relationship of presenting symptom burden and survival in patients with head and neck cancer (HNC)

Authors :
Gary Brandon Gunn
Jan S. Lewin
Charles S. Cleeland
Mark S. Chambers
S.J. Frank
Adam S. Garden
William H. Morrison
Tito R. Mendoza
X. S. Wang
David I. Rosenthal
Source :
Journal of Clinical Oncology. 28:5600-5600
Publication Year :
2010
Publisher :
American Society of Clinical Oncology (ASCO), 2010.

Abstract

5600 Background: Previous studies have shown that patient-reported outcomes with QOL instruments are predictive of survival. We investigate the relationship between HNC patient-reported symptoms and survival in addition to clinician ratings of ECOG performance status (PS). Methods: 129 patients with HNC participated in the study. Patients completed the M. D. Anderson Symptom Inventory - Head and Neck module (MDASI-HN) prior to radiotherapy or chemoradiotherapy. Cluster analysis was used to identify those who were symptomatic due to their disease prior to treatment. Cox regression was used to examine differences in survival between symptom burden groups with PS as covariate. Logistic regression was used to determine the relationship of overall survival status with symptom burden and performance status. Results: 46% (60/129) of HNC patients were identified to have symptoms prior to therapy. The top symptoms at presentation were fatigue, emotional distress, pain, disturbed sleep, drowsiness and sadness. Unde...

Details

ISSN :
15277755 and 0732183X
Volume :
28
Database :
OpenAIRE
Journal :
Journal of Clinical Oncology
Accession number :
edsair.doi...........4c9ce68c66673a13486438673332943e