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The relationship of presenting symptom burden and survival in patients with head and neck cancer (HNC)
- Source :
- Journal of Clinical Oncology. 28:5600-5600
- Publication Year :
- 2010
- Publisher :
- American Society of Clinical Oncology (ASCO), 2010.
-
Abstract
- 5600 Background: Previous studies have shown that patient-reported outcomes with QOL instruments are predictive of survival. We investigate the relationship between HNC patient-reported symptoms and survival in addition to clinician ratings of ECOG performance status (PS). Methods: 129 patients with HNC participated in the study. Patients completed the M. D. Anderson Symptom Inventory - Head and Neck module (MDASI-HN) prior to radiotherapy or chemoradiotherapy. Cluster analysis was used to identify those who were symptomatic due to their disease prior to treatment. Cox regression was used to examine differences in survival between symptom burden groups with PS as covariate. Logistic regression was used to determine the relationship of overall survival status with symptom burden and performance status. Results: 46% (60/129) of HNC patients were identified to have symptoms prior to therapy. The top symptoms at presentation were fatigue, emotional distress, pain, disturbed sleep, drowsiness and sadness. Unde...
- Subjects :
- Cancer Research
medicine.medical_specialty
Performance status
Proportional hazards model
business.industry
medicine.medical_treatment
Head and neck cancer
ECOG Performance Status
Disease
Logistic regression
medicine.disease
Radiation therapy
Oncology
Internal medicine
Physical therapy
medicine
business
Chemoradiotherapy
Subjects
Details
- ISSN :
- 15277755 and 0732183X
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Oncology
- Accession number :
- edsair.doi...........4c9ce68c66673a13486438673332943e